Table 6. Correlative studies between perfusion parameters on breast DCE MRI and prognostic factors.
Li's [27] | Koo's [23] | Kim's [13] | Yim's [22] | Present study | |
---|---|---|---|---|---|
Inclusion | Invasive cancer | Invasive cancer | DCIS, Invasive cancer | Invasive cancer | Invasive ductal carcinoma |
Case number | 37 | 70 | 50 | 64 | 81 |
MRI | 1.5T | 1.5T | 3T | 1.5T | 3T |
DCE model | Tofts | Tofts | Tofts | NM | Tofts |
Perfusion parameters | Ktrans, kep, ve, iAUC | Ktrans, kep, ve | Ktrans, kep, ve, iAUC | kep | Ktrans, kep, ve |
ROI | entire tumor on section | largest area on section | small area with high Ktrans | tumor margin | tumor volume |
Prognostic factors | subtype(TNC,L) | tumor size, LN, HG, NG, ER, PR, Ki-67, p53, Bcl-2, HER2, subtype (TNC,L,HER2) | tumor size, LN, HG, NG, ER, PR, HER2, EGFR, Bcl, CK5/6, Ki-67, subtype (TNC,L,HER2) | tumor size, HG, ER, HER2 | tumor size, LN, HG, ER, PR, HER2, subtype (TNC,L,HER2) |
Results | P(kep,TNC) N(ve,TNC) No-others | N(Ktrans,ER positivity) P(kep, HG) N(kep, ER positivity) P(kep, TNC)-TNC vs. L N(ve, TNC)-TNC vs. L | P(Ktrans, Ki-67 positivity) P(kep, ER positivity) P(kep, Ki-67 positivity) No-others | No-all | P(Ktrans, tumor size) No-others |
Note–M, not mentioned; ROI, region of interest on DCE MRI;LN,lymph node; HG, histologic grade; NG, nucelar grade; TNC, triple negative cancer subtype; L, luminal type; HER2, Her2 enriched type; P, positive correlation; N, negative correlation; No, no correlation