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. 2016 Dec 30;11(12):e0168632. doi: 10.1371/journal.pone.0168632

Table 6. Correlative studies between perfusion parameters on breast DCE MRI and prognostic factors.

Li's [27] Koo's [23] Kim's [13] Yim's [22] Present study
Inclusion Invasive cancer Invasive cancer DCIS, Invasive cancer Invasive cancer Invasive ductal carcinoma
Case number 37 70 50 64 81
MRI 1.5T 1.5T 3T 1.5T 3T
DCE model Tofts Tofts Tofts NM Tofts
Perfusion parameters Ktrans, kep, ve, iAUC Ktrans, kep, ve Ktrans, kep, ve, iAUC kep Ktrans, kep, ve
ROI entire tumor on section largest area on section small area with high Ktrans tumor margin tumor volume
Prognostic factors subtype(TNC,L) tumor size, LN, HG, NG, ER, PR, Ki-67, p53, Bcl-2, HER2, subtype (TNC,L,HER2) tumor size, LN, HG, NG, ER, PR, HER2, EGFR, Bcl, CK5/6, Ki-67, subtype (TNC,L,HER2) tumor size, HG, ER, HER2 tumor size, LN, HG, ER, PR, HER2, subtype (TNC,L,HER2)
Results P(kep,TNC) N(ve,TNC) No-others N(Ktrans,ER positivity) P(kep, HG) N(kep, ER positivity) P(kep, TNC)-TNC vs. L N(ve, TNC)-TNC vs. L P(Ktrans, Ki-67 positivity) P(kep, ER positivity) P(kep, Ki-67 positivity) No-others No-all P(Ktrans, tumor size) No-others

Note–M, not mentioned; ROI, region of interest on DCE MRI;LN,lymph node; HG, histologic grade; NG, nucelar grade; TNC, triple negative cancer subtype; L, luminal type; HER2, Her2 enriched type; P, positive correlation; N, negative correlation; No, no correlation