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. 2016 Dec 15;5:e20198. doi: 10.7554/eLife.20198

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© 2016, Volkov et al

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

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Figure 1. — (A) Reactions catalyzed by T. brucei S-adenosyl-L-methionine decarboxylase (TbAdoMetDC/prozyme heterodimer), ornithine decarboxylase (TbODC) and spermidine synthase (TbSpdSyn) are shown. AdoMet, S-adenosyl-L-methionine; dcAdoMet, decarboxylated S-adenosyl-L-methionine; MTA, methylthioadenosine. (B) CGP 40215 (CGP) is a competitive inhibitor of AdoMetDC (C) Bis-tris propane (B3P), a buffer component in the TbAdoMetDC/prozyme crystallization solution.

DOI: http://dx.doi.org/10.7554/eLife.20198.002