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. Author manuscript; available in PMC: 2017 Jan 15.
Published in final edited form as: J Neuroimmunol. 2016 Dec 1;302:10–19. doi: 10.1016/j.jneuroim.2016.11.012

Figure 3.

Figure 3

[A] The basic study layout consisted of a primary Tier 1 elimination by which all herbs were tested to reduce LPS/IFNγ induced NO-2 in C6 cells, with maximum working concentrations : 230μg/mL (herbal extracts) and <92μg/ml (metabolites, drugs and polyphenolics). [B] Compounds displaying an IC50 below 1st Tier concentrations were further evaluated where toxicity/anti-inflammatory effects were evaluated simultaneously and an in vitro efficacy index iEI differential is established (LC50/IC50).