TABLE 1.

Mutations of virulence regulators in Sse^A− SpeB^A+, Sse^A+ SpeB^A+, and Sse^A+ SpeB^A− isolates from mice with subcutaneous MGAS2221 infection

Isolate	Mouse no.	Activity in culture supernatant		Mutation
		Sse	SpeB	rocA	covRS
M27	1	+	+	C605A	wta
M76	2	+	+	G insertion at 205	wt
M108	3	+	+	C605A	wt
M116	3	+	+	C605A	wt
M122	3	+	+	C605A	wt
M138	3	+	+	204TGATGTT insertion	wt
M153	4	+	+	1228A deletion	wt
M100	4	+	−	wt	covSΔ133TTCTT137
M177	4	−	+	wt	wt

^awt, wild type.