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. 2016 Dec 29;85(1):e00552-16. doi: 10.1128/IAI.00552-16

FIG 3.

FIG 3

MK2 regulates chemokines in A. actinomycetemcomitans-challenged macrophages and in vivo. (A) RT-qPCR of Ccl3 and Ccl4 gene expression of Mk2+/+ and Mk2−/− BMDMs stimulated with 10 CFU of A. actinomycetemcomitans (A.a.) per cell or untreated control Mk2+/+ and Mk2−/− BMDMs (n = 3 to 4). (B) RT-qPCR of Ccl3 (left) and Ccl4 (right) gene expression in mouse calvarial tissue challenged with A. actinomycetemcomitans or PBS vehicle for 3 days (n = 3 to 7). (C) Multiplex assay of mouse tissue chemokines after 3 days of A. actinomycetemcomitans treatment (n = 4). (D) Multiplex assay of mouse peripheral blood chemokines after 3 days of A. actinomycetemcomitans treatment (n = 4). Data are expressed as means ± SEMs. *, P ≤ 0.05; **, P ≤ 0.01.