FIG 5.

Interindividual variability of the response against Candida spp. The variability of the subjects' response against Candida infection was studied after infection of human peripheral blood mononuclear and polymorphonuclear cells with living yeasts from different Candida species. (A) Fungal burden 6 days postinfection. Results are expressed as the mean ± SEM of the fungal burden of 4 Candida clinical isolates from each species for each subject (S1 to S10). Dotted lines indicate the arbitrary cutoff of 100 CFU/ml. The mean ± SEM for each subject and each Candida species were compared to the mean ± SEM of species that controlled infection (mean of C. krusei and C. kefyr). *, P < 0.05; **, P < 0.001. (B) Number of subjects showing a persistent-infection (white bars) or controlled-infection (green bars) status.