Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Dec 29;85(1):e00807-16. doi: 10.1128/IAI.00807-16

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Misme-Aucouturier et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

PMC Copyright notice

FIG 8 — Characterization of CD4⁺ and CD8⁺ T cells within Candida granuloma-like structures over time. Peripheral blood mononuclear and polymorphonuclear cells from 10 subjects were infected with 32 Candida clinical isolates for up to 6 days. The granuloma-like structures were collected from coculture plates at different time points and stained with a cocktail of fluorescence-conjugated antibodies specific to CD3, CD4, and CD8 lymphocytes. (A) Representative flow cytometry analysis showing CD4⁺ and CD8⁺ cells over time after gating on CD3⁺ lymphocytes. (B and C) The proportions of CD4⁺ and CD8⁺ cells within granuloma-like structures are expressed as percentages of the total CD3⁺ compartment. Box plots depict median, minimum, and maximum percentages of CD4⁺ and CD8⁺ cells over time according to infection status. (D) Dynamics of CD4⁺/CD8⁺ cell ratio over time between persistent-infection and controlled-infection granuloma-like structures. *, P < 0.05; **, P < 0.001; ***, P < 0.0001; ****, P < 0.00001 (by one-way ANOVA with Tukey's multiple-comparison test) (n = 320).