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HIF-1α downregulation by NDV was partially abrogated by proteasomal inhibition in hypoxic condition. Saos-2 (a) and MCF-7 (b) cells were infected with NDV under 21 % O2 or 0.5 % O2 in the presence or absence of bortezomib (BZ). Samples were harvested at 25 h post-infection, and the levels of HIF-1α and CAIX proteins were examined.
