Table II.
Clinical characteristics and serum hormone concentrations in women with the polycystic ovary syndrome after administration of insulin-sensitizing drugs for three months
| Variable |
Metformin
|
Pioglitazone
|
Combination
|
p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
Pre
treatment |
Post
treatment |
p-value |
Pre
treatment |
Post
treatment |
p-value |
Pre
treatment |
Post
treatment |
p-value | ||
| Weight(kg) | 71.3±11.2 | 71±12.8 | NS | 70.6±13.2 | 72.1±13.1 | <0.001 | 72.6±9.4 | 71.5±9.8 | NS | NS |
| BMI(kg/m2) | 27.5±3.6 | 27.4±4.4 | NS | 27.2±4.7 | 27.8±4.7 | <0.001 | 28.5±3.2 | 28±3.4 | NS | NS |
| Waist-to-hip ratio | 0.83±0.031 | 0.83±0.036 | NS | 0.80±0.055 | 0.81±0.055 | 0.001 | 0.82±0.045 | 0.82±0.049 | NS | NS |
| Fasting glucose (mmol/l) | 5.4±0.5 | 5.1±0.3 | 0.012 | 5±0.2 | 4.8±0.2 | 0.018 | 5.1±0.5 | 5±0.4 | NS | 0.02 |
| Fasting insulin (µU/ml) | 17.1±10.8 | 10.3±5.6 | 0.003 | 12.4±7.1 | 8.6±4.9 | 0.015 | 11.7±7.5 | 7.3±4.3 | 0.026 | NS |
| HOMA-IR | 4.2±2.7 | 2.3±1.2 | 0.001 | 2.8±1.6 | 1.8±1 | 0.011 | 2.7±1.8 | 1.6±0.8 | 0.013 | NS |
| QUICKI | 0.31±0.03 | 0.34±0.03 | 0.001 | 0.33±0.02 | 0.35±0.03 | 0.007 | 0.33±0.03 | 0.36±0.03 | 0.009 | NS |
| Fasting G/I ratio (mg/dL per µIU/mL) | 7.8±5.3 | 14.6±12.4 | 0.008 | 9.5±4.7 | 13.9±8.9 | 0.026 | 10.6±6.3 | 15.7±7.5 | 0.03 | NS |
| LDL cholesterol (mg/dl) | 131.8±26.7 | 127±28 | NS | 113.8±54.8 | 110±52.6 | NS | 126.9±33.5 | 124±29.8 | NS | NS |
| HDL cholesterol (mg/dl) | 51.1±12.1 | 52.9±11 | NS | 51.1±12.5 | 52.8±12.5 | NS | 52.2±12.2 | 55.7±13.2 | NS | NS |
| Serum cholesterol (mg/dl) | 215±36.5 | 209.7±37.2 | NS | 185.6±51.6 | 177.7±53.3 | NS | 196±36.6 | 197±35.6 | NS | NS |
| Serum triglyceride (mg/dl) | 140.3±58.2 | 147±78.9 | NS | 111.6±76 | 100.9±61.8 | NS | 131±59.3 | 114.3±78.5 | NS | NS |
| DHEAS (mg/l) | 1.5±0.7 | 1.4±0.5 | NS | 1.4±0.7 | 1.6±0.6 | NS | 1.4±0.7 | 1.5±0.8 | NS | NS |
| Total testosterone (µg/l) | 0.7±0.2 | 0.6±0.18 | 0.018 | 0.7±0.1 | 0.7±0.2 | NS | 0.6±0.2 | 0.6±0.1 | NS | NS |
| FSH (IU/L) | 5.2±1.7 | 5.5±1.4 | NS | 4.7±1.2 | 5.6±2.1 | 0.041 | 5.6±2.2 | 7±2.2 | 0.005 | 0.01 |
| LH(IU/L) | 7.9±2.3 | 6.3±2.4 | 0.002 | 7.6±2.9 | 6.3±2.4 | NS | 6.8±2.7 | 6.4±2.2 | NS | NS |
| LH/FSH | 1.6±0.6 | 1.1±0.4 | 0.002 | 1.6±0.8 | 1.1±0.4 | 0.07 | 1.4±0.7 | 1±0.5 | 0.003 | NS |
Note: Plus-minus values are means ± SD. To convert values for fasting glucose to mmol/L, multiply by 0.05551.
BMI: Body Mass Index
HOMA-IR: Homeostatic model assessment of insulin resistance.
QUICKI: Quantitative insulin check index
G/I: Fasting glucose to fasting insulin ratio
DHEA-S: Dehydroepiandrosterone sulphate
FSH: Follicle stimulating hormone.
LH: Luteinizing hormone
mmol/l: milimol per liter
µU/ml: micro Units per milliliter
mg/dL: microgram per deciliter
µg/l: microgram per liter
NS; Non-significant