Table 2. Diagnostic Performance of LS, APRI, FIB-4, AST/ALT, FibroQ, NAFLD Fiibrosis Score, and Fiibrosis Score by Gutkowski for Determination of Fiibrosis Stage.

Variable	AUC ± SE	Optimal Cut-Off	Sensitivity (%)	Specificity (%)	Positive Predictive Value (%)	Negative Predictive Value (%)	P
F1 versus F2 - 4
LS, kPa	0.779 ± 0.08	10.05	61.4	88.9	96.4	31.8	0.009
APRI	0.601 ± 0.09	1.45	59.1	67	89.7	25.1	0.343
FIB-4	0.659 ± 0.08	3.2	47.7	88.9	95.5	26	0.136
AST/ALT	0.601 ± 0.09	0.718	52.3	77.8	92	25	0.343
FibroQ	0.684 ± 0.09	1.34	72.7	66.7	91.5	33.7	0.084
NAFLD fiibrosis score	0.752 ± 0.1	-2.6	71.4	66.7	91.3	32.1	0.051
Fiibrosis score Gutkowski	0.433 ± 0.12	2.96	45.7	66.7	87.2	20.3	0.606
F1-2 versus F3 - 4
LS, kPa	0.739 ± 0.07	12.1	58.6	83.3	80.9	62.4	0.003
APRI	0.527 ± 0.08	1.24	69	50	62.8	59.9	0.734
FIB-4	0.614 ± 0.08	1.93	75.9	50	65	35	0.158
AST/ALT	0.655 ± 0.08	0.795	48.3	75	70.1	54.1	0.054
FibroQ	0.773 ± 0.06	2.695	58.6	91.7	90	64.7	0.001
NAFLD fiibrosis score	0.895 ± 0.05	-3.23	92.3	66.7	77.3	87.3	< 0.0001
Fiibrosis score Gutkowski	0.605 ± 0.1	2.599	80.8	53.3	68.1	70.7	0.267
F1-3 versus F4
LS, kPa	0.842 ± 0.09	19	81.8	92.9	75.7	95.1	0.001
APRI	0.665 ± 0.08	1.848	81.8	57.1	33.6	92.3	0.096
FIB-4	0.766 ± 0.08	2.61	90.9	59.5	37.7	96	0.007
AST/ALT	0.799 ± 0.08	0.939	63.6	88.1	58.6	90.2	0.002
FibroQ	0.916 ± 0.06	3.999	81.8	92.9	75.7	95.1	< 0.0001
NAFLD fiibrosis score	0.910 ± 0.05	-1.095	90	87.1	64.8	97	< 0.0001
Fiibrosis score Gutkowski	0.619 ± 0.09	2.66	90	45.2	30.3	94.4	0.261

Abbreviations: AUC, area under the curve, SE, standard error.