Table 1.
Results of Single Marker Associations for Bipolar II Disorder
| SNP | CHR: Position | Mapped Gene | Minor/Major Allele | Chip / Impute | Discovery Samples | Replication Samples | Meta-Analysis P Value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF (case/control) | P Value | OR | MAF (case/control) | P Value | OR | ||||||
| rs3789559 | 1:6105109 | KCNAB2 | T/C | Chip | 0.425/0.314 | 2.1×10–6 | 1.76 | 0.320/0.318 | 0.92 | 1.01 | 5.5×10–6 |
| rs3789560 | 1:6104715 | KCNAB2 | G/A | Impute | 0.427/0.317 | 2.4×10–6 | 1.77 | 0.322/0.322 | 0.98 | 1.00 | 6.2×10–6 |
| rs3789556 | 1:6108863 | KCNAB2 | G/A | Impute | 0.415/0.300 | 2.5×10–6 | 1.78 | 0.306/0.308 | 0.97 | 0.99 | 6.5×10–6 |
| rs77034375 | 4:88815986 | Nearby HSP90AB3P | T/C | Impute | 0.124/0.062 | 1.9×10–6 | 2.53 | 0.096/0.057 | 7.0×10–3 | 1.76 | 6.8×10 –7 |
| rs3828554 | 4:88813875 | Nearby HSP90AB3P | C/T | Impute | 0.121/0.060 | 2.9×10–6 | 2.53 | 0.096/0.055 | 4.0×10–3 | 1.84 | 6.6×10 –7 |
| rs62318301 | 4:88811182 | Nearby HSP90AB3P | G/A | Impute | 0.119/0.059 | 4.9×10–6 | 2.49 | 0.093/0.055 | 6.0×10–3 | 1.79 | 1.5×10 –6 |
| rs114640425 | 4:37761675 | G/C | Impute | 0.143/0.075 | 3.2×10–6 | 2.49 | 0.103/0.066 | 1.7×10–2 | 1.60 | 2.2×10 –6 | |
| rs6991165 | 8:57435745 |
LOC100507632
(LINC00968) |
A/G | Chip | 0.481/0.353 | 4.8×10–6 | 1.70 | 0.373/0.374 | 0.96 | 0.99 | 1.2×10–5 |
| rs10887909 | 10:90857775 | A/G | Impute | 0.438/0.326 | 2.9×10–6 | 1.73 | 0.384/0.320 | 1.5×10–2 | 1.32 | 1.8×10 –6 | |
| rs9583266 | 13:109250314 | MYO16 | A/G | Impute | 0.195/0.105 | 1.7×10–6 | 2.06 | 0.140/0.109 | 8.0×10–2 | 1.35 | 3.0×10 –6 |
| rs2182501 | 13:109255438 | MYO16 | C/T | Impute | 0.196/0.108 | 3.3×10–6 | 2.01 | 0.143/0.109 | 6.0×10–2 | 1.38 | 5.0×10 –6 |
| rs66581286 | 13:109259587 | MYO16 | A/G | Impute | 0.193/0.106 | 3.6×10–6 | 2.01 | 0.137/0.106 | 0.09 | 1.34 | 6.7×10–6 |
| rs11619281 | 13:109225931 | G/A | Impute | 0.231/0.138 | 3.6×10–6 | 2.27 | 0.179/0.150 | 0.14 | 1.25 | 7.9×10–6 | |
| rs34497953 | 13:109226359 | C/T | Impute | 0.231/0.138 | 3.6×10–6 | 2.27 | 0.179/0.150 | 0.14 | 1.25 | 7.9×10–6 | |
| rs35218525 | 13:109179086 | G/A | Impute | 0.243/0.148 | 4.0×10–6 | 1.89 | 0.187/0.161 | 0.19 | 1.22 | 9.5×10–6 | |
| rs11616644 | 13:109169847 | C/T | Impute | 0.232/0.139 | 4.0×10–6 | 1.90 | 0.187/0.155 | 0.11 | 1.27 | 8.0×10–6 | |
| rs11616603 | 13:109171415 | G/A | Impute | 0.236/0.142 | 4.0×10–6 | 1.89 | 0.188/0.158 | 0.13 | 1.25 | 8.5×10–6 | |
| rs11616630 | 13:109171673 | C/A | Impute | 0.236/0.143 | 4.1×10–6 | 1.89 | 0.188/0.158 | 0.13 | 1.25 | 8.7×10–6 | |
| rs4771589 | 13:109182384 | T/G | Impute | 0.243/0.149 | 4.2×10–6 | 1.89 | 0.187/0.161 | 0.19 | 1.22 | 9.9×10–6 | |
| rs71439369 | 13:109196377 | T/C | Impute | 0.237/0.143 | 4.6×10–6 | 1.88 | 0.183/0.160 | 0.25 | 1.19 | 1.1×10–5 | |
| rs1924345 | 13:109189032 | C/T | Impute | 0.243/0.149 | 4.6×10–6 | 1.88 | 0.191/0.162 | 0.14 | 1.24 | 1.0×10–5 | |
| rs1924348 | 13:109191801 | G/A | Impute | 0.236/0.143 | 4.8×10–6 | 1.88 | 0.188/0.159 | 0.14 | 1.25 | 1.0×10–5 | |
| rs2147148 | 13:109190538 | G/A | Impute | 0.236/0.143 | 4.8×10–6 | 1.88 | 0.188/0.159 | 0.14 | 1.25 | 1.0×10–5 | |
| rs61212586 | 14:86123937 | Nearby FLRT2 | A/G | Impute | 0.275/0.163 | 4.6×10–6 | 1.94 | 0.150/0.153 | 0.84 | 0.97 | 1.2×10–5 |
| rs16941261 | 15: 88655520 | NTRK3 | C/G | Impute | 0.129/0.069 | 3.9×10–6 | 2.57 | 0.068/0.070 | 0.87 | 0.96 | 1.0×10–5 |
Abbreviations: CHR, chromosome; MAF, minor allele frequency; SNP, single nucleotide polymorphism.
Association analyses using logistic regression with an additive model while adjusted for gender and age.
P values in meta-analysis were calculated based on the inverse gamma method and we reported SNPs (highlighted in gray) with combined P value <5×10–6.