Table 2.
Results of Gene-Based Association Analyses for Bipolar II Disorder
| Gene | Number of SNPs within a Gene | Number of SNPs Having P < .1 | Number of SNPs Having P < .1 and r2<0.5 | Empirical P Value | ||||
|---|---|---|---|---|---|---|---|---|
| Discovery Samples | Replication Samples | Discovery Samples | Replication Samples | Discovery Samples | Replication Samples | Discovery Samples | Replication Samples | |
| AL355490.1 | 59 | 58 | 1 | 1 | 1 | 1 | 2.0×10–5 | .25 |
| RRP12 | 190 | 182 | 4 | 3 | 1 | 1 | 2.0×10–5 | .28 |
| KCNAB2 | 40 | 40 | 7 | 0 | 2 | 0 | 1.0×10–4 | 1 |
| TLL2 | 377 | 375 | 2 | 6 | 1 | 2 | 1.2×10–4 | .89 |
| PJA2 | 42 | 37 | 1 | 2 | 1 | 1 | 3.6×10–4 | .33 |
| VSIG10 | 126 | 111 | 12 | 6 | 1 | 2 | 3.8×10–4 | .41 |
| CDKL4 | 78 | 75 | 66 | 8 | 1 | 1 | 4.2×10–4 | .15 |
| IWS1 | 204 | 198 | 111 | 17 | 3 | 2 | 4.4×10–4 | .36 |
| MAP4K3 | 203 | 194 | 160 | 6 | 1 | 1 | 4.8×10–4 | .46 |
| ETF1 | 52 | 51 | 38 | 50 | 1 | 1 | 4.9×10–4 | 6.0×10–3 |
We reported genes with empirical P < 5×10–4 based on 50,000 permutations in the discovery samples. All models were adjusted for gender and age. Gene highlighted in gray was successfully replicated in the replication samples.