Table 4.

Estimation of Variance Explained by Genome-Wide SNPs

Sample	Genetic Variance, Vg (s.e.)	Residual Variance, Ve (s.e.)	Phenotypic Variance, Vp (s.e.)	Heritability Estimate, h2 (s.e.)
				Not Adjusted by Disease Prevalence	Adjusted by Disease Prevalence
					0.01	0.02	0.03	0.04	0.05
Discovery	0.0684 (0.019)	0.0938 (0.019)	0.1622 (0.005)	0.4217 (0.119)	0.3585 (0.101)	0.4258 (0.120)	0.4753 (0.134)	0.5160 (0.146)	0.5511 (0.156)
Replication	0.1481 (0.074)	0.0798 (0.073)	0.2279 (0.012)	0.6498 (0.320)	0.3933 (0.193)	0.4671 (0.230)	0.5214 (0.256)	0.5660 (0.279)	0.6047 (0.297)

h ² =Vg/ Vp represents the estimate of variance explained by the genome-wide SNPs on the observed scale. Adjusted h ² represents the estimate of variance explained by genome-wide SNPs, taking into account the prevalence of bipolar II disorder from the general population.