Table 5.
Results of the Pathway Enrichment Analysis for Bipolar II Disorder
| Pathway | No. Genes in Gene-Set | # Genes Overlapping with Our Gene List | P Value | Adjusted P Value |
|---|---|---|---|---|
| Neurological system process (GO) | 379 | 18 | 3.4×10–8 | 1.2×10–5 |
| Transmembrane transporter activity (GO) | 375 | 17 | 1.6×10–7 | 3.1×10–5 |
| Apoptosis (GO) | 431 | 17 | 1.1×10–6 | 1.6×10–4 |
| Programmed cell death (GO) | 432 | 17 | 1.1×10–6 | 1.6×10–4 |
| Developmental biology (Reactome) | 396 | 16 | 1.6×10–6 | 1.9×10–4 |
| Neuronal system (Reactome) | 279 | 13 | 3.3×10–6 | 3.3×10–4 |
| Gastrin CREB signaling pathway via PKC and MAPK (Reactome) | 205 | 11 | 5.0×10–6 | 4.6×10–4 |
| Regulation of apoptosis (GO) | 341 | 14 | 6.1×10–6 | 5.1×10–4 |
| Axon guidance (Reactome) | 251 | 12 | 6.1×10–6 | 5.1×10–4 |
| Regulation of development process (GO) | 440 | 16 | 6.2×10–6 | 5.1×10–4 |
| Regulation of programmed cell death (GO) | 342 | 14 | 6.3×10–6 | 5.1×10–4 |
| Substrate specific transporter activity (GO) | 392 | 15 | 6.6×10–6 | 5.2×10–4 |
| Substrate specific transmembrane transporter activity (GO) | 344 | 14 | 6.7×10–6 | 5.2×10–4 |
| G alpha Q signaling events (Reactome) | 184 | 10 | 1.2×10–5 | 8.8×10–4 |
| Transmission across chemical synapses (Reactome) | 186 | 10 | 1.3×10–5 | 9.4×10–4 |
| Sensory perception (GO) | 190 | 10 | 1.6×10–5 | 1.1×10–3 |
| Ion transmembrane transporter activity (GO) | 278 | 12 | 1.7×10–5 | 1.2×10–3 |
| Ligase activity (GO) | 97 | 7 | 4.1×10–5 | 2.4×10–3 |
| Cell adhesion molecules (CAMs) (KEGG) | 134 | 8 | 4.6×10–5 | 2.6×10–3 |
| MAPK signaling pathway (KEGG) | 267 | 11 | 5.8×10–5 | 3.2×10–3 |
| Neuroactive ligand receptor interaction (KEGG) | 272 | 11 | 6.8×10–5 | 3.7×10–3 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) (KEGG) | 76 | 6 | 8.9×10–5 | 4.5×10–3 |
| Nervous system development (GO) | 385 | 13 | 9.6×10–5 | 4.7×10–3 |
| Ion channel activity (GO) | 149 | 8 | 9.7×10–5 | 4.7×10–3 |
Abbreviations: GO, Gene Ontology terms; KEGG, Kyoto Encyclopedia of Genes and Genomes.
P values were calculated using hypergeometric test; adjusted p-values were computed using the Bonferroni correction. We reported pathways with P < 5×10–3 after Bonferroni correction. Our gene list consists of 452 genes that selected from gene-based association analysis (only genes with P < .01) and single-marker association analysis (only genes with at least one SNP having P < .001) for pathway analysis.