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. 2016 Aug 9;19(12):pyw069. doi: 10.1093/ijnp/pyw069

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© The Author 2016. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — The microRNA (miRNA) assay identified 23 miRNAs with lower expression levels in the prefrontal cortex (PFC) of the Flinders Sensitive Line (FSL) depression model (supplementary Table 2), and we selected 9 of them for individual validation experiments. Eight of the 9 miRNAs reached statistical significance (miR-10a, P=.046; miR-101b, P = .011; miR-107, P = .02; miR-124, P = .03; miR-125a, P = .048; miR-125b, P = .2; miR-133a, P = .03; miR-181a, P = .032, and miR-199a, P = .029). Data are presented as relative quantifications (R.Q.) ± SEM. Levels of Rnu5g were used as reference for normalization of mature miRNA expression levels (n = 6–7 animals/group; n = 1 outlier/group),*P < .05.