Figure 2.
Antidepressant effects of (+)-MK-801 and (-)-MK-801 in social defeat stress model. Behavioral tests were performed as described in the Figure 1. A: LMT (day 12), B: TST (day 12), C: FST (day 13), D: SPT (day 14) E: SPT (day 16) and F: SPT (day 19). The values represent the mean ± SEM (n = 9 or 10). *P < .05, ** P < .01, *** P < .001 compared with the vehicle-treated stress group. Con: control; Veh: vehicle; (+)MK: (+)-MK-801; (-)MK: (-)-MK-801; LMT: locomotion test; TST: tail suspension test; FST: forced swimming test; SPT: 1% sucrose preference test.