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. 2016 Nov 9;8(11):3529–3544. doi: 10.1093/gbe/evw252

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© The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 5.— — Permutation of miRNA–mRNA target relationships at the lineage level. (A) The empirical distribution of the Pearson’s correlation coefficient values for 436 miRNA–mRNA pairs between expression levels of 96 miRNAs and those of their target mRNAs across 6 lineages. (B) The histogram plot represents the distribution of the global mean correlation values for the expression levels of all miRNA–mRNA pairs for 1,000 permutations, (C) for the highly conserved miRNAs and (D) for the lowly conserved miRNAs. The black arrowhead indicates the true value.