Fig. 1.
Influence of AM251 on the increases in systolic, diastolic and mean blood pressure (SBP, DBP, MBP) and heart rate (HR) induced by NMDA microinjected into the paraventricular nucleus (PVN) in urethane-anaesthetized rats. NMDA was administered twice (S1 and S2, 20 min apart). AM251 3 μmol/kg or its solvent was administered i.v. 5 min before S2. Results are calculated as percentage of basal values determined immediately before S1 and S2 (see Table 1). Means ± SEM of 4 rats. *P < 0.001 compared to the corresponding S1; # P < 0.05; ### P < 0.001 compared to the corresponding S2 values without AM251