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. 2016 Apr 6;21(1):453–461. doi: 10.1007/s00784-016-1813-4

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — BrdU incorporation by gingival fibroblasts after stimulation with a 5 % concentration of the soluble compounds from child dentifrices. Proliferation was expressed as BrdU incorporation during DNA synthesis. The percentage of BrdU incorporation was normalized to untreated cells. Dentifrices that resulted in LC50 values between 5 and 20 % (dark-gray bars) showed in the BrdU incorporation assay similar values to dentifrices that achieved LC50 values of more than 90 % (light-gray bars). Dentifrices with LC50 values below 5 % exhibited decreased BrdU values (black bars)