Table 3.

Circulating miRNAs of lowest expression in CLL patients (fold change compared to the reference sample)

miRNA	Number	Mean	Median	Minimum	Maximum	Std. deviation
miR-147a	22	0.015611	0.002544	0.000000	0.21399	0.046501
miR-184	22	0.032830	0.000000	0.000000	0.62236	0.132337
miR-326	22	0.060900	0.021956	0.000000	0.83752	0.17533
miR-18a-5p	22	0.103611	0.056592	0.000000	0.41750	0.113735
miR-195-5p	22	0.107020	0.057505	0.000458	0.54184	0.127800
miR-25-3p	22	0.109736	0.062301	0.001780	0.52281	0.13023
let-7d-5p	22	0.112145	0.058179	0.006802	0.442157	0.119731
miR-130b-3p	22	0.113208	0.062630	0.000000	0.461458	0.121767
miR-191-5p	22	0.116295	0.065128	0.004588	0.60537	0.150365
miR-30c-5p	22	0.127434	0.052519	0.008106	0.44780	0.14150
let-7e-5p	22	0.131160	0.063212	0.012399	0.513795	0.138210
miR-19a-3p	22	0.132547	0.087024	0.005614	0.48952	0.135557
miR-17-5p	22	0.132640	0.087608	0.005313	0.48162	0.128858
miR-16-5p	22	0.132781	0.079348	0.000449	0.77485	0.175928
miR-30b-5p	22	0.136220	0.076458	0.006022	0.42131	0.13321
miR-30d-5p	22	0.136391	0.075910	0.003105	0.56710	0.15640
miR23b-3p	22	0.137499	0.064416	0.003837	0.62679	0.16386
let-7f-5p	22	0.146194	0.072787	0.011085	0.552243	0.160592
let-7a-5p	22	0.147019	0.088026	0.005797	0.510367	0.155073
miR-182-5p	22	0.153754	0.052493	0.000000	1.10934	0.254892
miR-26a-5p	22	0.161983	0.087658	0.001916	0.67649	0.17815
miR-98-5p	22	0.173266	0.039254	0.000000	1.06964	0.29938
miR-142-5p	22	0.174660	0.086560	0.006512	0.61231	0.190252
miR-26b-5p	22	0.181229	0.098017	0.005669	0.71576	0.19998
miR222-3p	22	0.189829	0.091111	0.000000	1.13503	0.26830
miR-181c-5p	22	0.196126	0.099759	0.000000	0.94699	0.244802
miR-15b-5p	22	0.199360	0.078987	0.008995	1.47413	0.343739
miR-181b-5p	22	0.207683	0.088729	0.000000	0.90124	0.264372
miR-214-3p	22	0.212431	0.066792	0.000000	1.65352	0.36579
miR-24-3p	22	0.224084	0.095890	0.000000	1.39993	0.33267
miR-132-3p	22	0.237720	0.090168	0.000000	1.859543	0.402654
miR-27b-3p	22	0.244229	0.096800	0.027010	1.32214	0.36012
miR-17-3p	22	0.300520	0.084771	0.000000	1.40011	0.401672
miR-92a-3p	22	0.390319	0.049988	0.000600	5.51859	1.20007
miR-93-5p	22	0.439960	0.071626	0.000000	7.10019	1.49466
miR223-3p	22	0.446638	0.073717	0.000000	5.64799	1.18569

Expression values were presented as the logarithm of R to the base 2, where R was calculated as follows: R = 2^−ΔΔCt, ΔΔCt = ΔCt of CLL patient − ΔCt of normal individuals, every ΔCt = Ct of miRNA examined − Ct of endogenous control, 1 − mean expression in pooled miRNAs of normal individuals