Table 7.

P values of the most significant differences in serum expression of miRNA classified into functional groups depending on prognostic factors

miRNa expression—functional groups	Age <65 vs ≥65	WBC <35 × 109 vs ≥35 × 109/L	CD38 <30 vs ≥30 %	B2M <3 vs ≥3 mg/L	LDH <480 vs ≥480 IU/L	IGVH mut vs unmut	NOTCH1 mut vs unmut	ATM deleted vs wt	chrom 12 trisomy vs n12
B cell differentiation
Naive	0.0018	0.0034	<0.0001	0.0008	0.0103	0.0376	0.0011	0.0130	<0.0001
Germinal center	<0.0001	<0.0001	<0.0001	<0.0001	0.0117	0.0115	0.0125	–	<0.0001
Memory	0.0005	0.0002	0.0001	0.0024	0.0440	–	0.0462	0.0111	<0.0001
T cell differentiation
Double negativea	0.0008	<0.0001	<0.0001	<0.0001	0.0020	0.0050	0.0006	0.0033	<0.0001
Double positiveb	–	–	0.0001	0.0007	–	0.0169	0.0347	0.0019	0.0006
CD4+ naive	–	0.0063	–	0.0059	–	–	–	–	0.0151
CD8+ naive	0.0052	0.0064	<0.0001	0.0008	0.0124	0.0317	0.0189	0.0081	<0.0001
CD8+ effector	–	–	0.0024	0.0009	–	–	–	–	0.0013
CD8+ memory	0.0005	0.0135	0.0007	–	–	–	–	–	<0.0001
T cell activation	<0.0001	<0.0001	<0.0001	<0.0001	0.0193	0.0051	0.0009	0.0017	<0.0001
Tregs	<0.0001	<0.0001	0.0002	0.0003	–	0.0388	0.0093	0.0006	0.0041

For data analysis, the Kruskal-Wallis test was used. Dashes stand for no statistical differences. See Table 6 for the direction of the particular difference

mut mutated, unmut unmutated, wt wild type, n12 normal number of chromosomes 12

^aCD4−/CD8−

^bCD4+/CD8+