Table 5.
Plasma and CSF concentrations of 17 metabolites in control and AD subjects (mean ± SD)
| Analyte | Plasma | CSF | Units | ||
|---|---|---|---|---|---|
| Control (n = 6) | AD (n = 6) | Control (n = 6) | AD (n = 6) | ||
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||
| Homocysteic acid | <LOD | <LOD | <LOD | <LOD | μM |
| Taurine | 81.5 ± 30.9 | 71.6 ± 18 | 27.8 ± 4.7 | 24.0 ± 4.8 | μM |
| Serine | 79.6 ± 15.7 | 85.8 ± 19.4 | 25.4 ± 4.8 | 32.9 ± 14.5 | μM |
| Total cysteine | 144.4 ± 9.9 | 153.2 ± 32.9 | 1.1 ± 0.4 | 2.4 ± 2.2 | μM |
| Glycine | 250.0 ± 112.1 | 339.3 ± 180.6 | 7.8 ± 4.4 | 25.6 ± 20.3 | μM |
| Total homocysteine | 5.3 ± 1.6 | 8.1 ± 6.9 | <LOQ | <LOQ | μM |
| Riboflavin | 68.2 ± 66.6 | 21.9 ± 30.7 | 6.7 ± 5.3 | 12.9 ± 6.5 | nM |
| Methionine | 16.9 ± 2.8 | 16.8 ± 3.4 | 3.7 ± 0.4 | 5.3 ± 1.6 | μM |
| Pyridoxine | <LOD | <LOD | <LOD | <LOD | nM |
| Cystathionine | 116.7 ± 34.2 | 175.7 ± 112.3 | 46.0 ± 36.7 | 42.0 ± 32.9 | nM |
| SAH | 25.7 ± 9.9 | 40.9 ± 9.8 | 14.3 ± 2.5 | 26.1 ± 9.4 | nM |
| Pyridoxamine | <LOD | <LOD | <LOD | <LOD | nM |
| SAM | 88.5 ± 18.1 | 68.5 ± 19.4 | 191.4 ± 31.1 | 150.7 ± 30.2 | nM |
| DMG | <LOQ | <LOQ | <LOQ | <LOQ | μM |
| Betaine | 45.9 ± 14.5 | 45.8 ± 17.0 | <LOD | <LOD | μM |
| Choline | 11.2 ± 3.5 | 11.6 ± 3.7 | 3.0 ± 0.7 | 3.5 ± 0.5 | μM |
| 5-MTHF | 56.6 ± 23.3 | 191.9 ± 363.5 | 60.9 ± 11.8 | 57.4 ± 18.8 | nM |