Fig. 4.

Map2k7 ^+/− mice have a higher intra-individual reaction time variability for incorrect, but not correct, response times than WT mice throughout baseline that was not significantly alleviated by minocycline treatment (a, b). Increased variability also occurred for Map2k7 ^+/− mice compared to WTs on average on a day-to-day basis, seen during training to a vITI and baseline performance for latency to incorrect (e) but not correct responses (c). d, f The standard deviations of each group over the course of the last 5-day stable performance (baseline). Data was analysed by either a two-way repeated measures ANOVA with daily session as a within subject factor, genotype as a between subject factor, with each individual mouse nested within genotype (data from a to e), or a one-tailed t test between genotypes (data from d andf). Data are presented as mean ± standard error of the mean (SEM). *p < 0.05 (vs. WT), N _WT = 15, N _Map2k7+/− = 16