Figure 6.

Disturbed expression of EphB4, but not ephrinB2, significantly retarded bone regeneration in an inflammatory microenvironment created in mice. (a–i) At 7 days (a–c), 14 days (d–f), and 21 days (g–i) after surgery, new bone tissue could be observed in the pLenti6.3-ctrl group (a, d, g), the pLenti6.3-efnb2siRNA group (b, e, h), and the pLenti6.3-ephb4siRNA group (c, f, i). (j) Statistical analysis of the newly formed bone area among the three groups; nb, new bone; scale bars, 50 μm; ^∗∗ p < 0.001 versus pLenti6.3-ctrl group.