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Effects of JP-1 on the AMPK/mTOR and CDK6/pRb cascades in A549 cells. (a) JP-1 decreased the protein levels of CDK6 and phosphorylated pRb (p-pRb) in a dose-dependent manner after 48 h of treatment. (b) JP-1 dose-dependently increased the phosphorylated AMPKα protein (p-AMPKα) and decreased the phosphorylated mTOR (p-mTOR) after 48 h of treatment. Cell lysates were analyzed by Western blot, using GAPDH as the loading control.
