Fig. 1.

TTC (2,3,5-triphenyltetrazolium chloride) staining analysis of brain slices. Infarction (white area) is shown in MCAO group. Infarct regions, especially in cortex decreased in SA treated animals at 2 mm, 4 mm, 6 mm and 8 mm from the anterior pole (only 4 mm one showed in this figure) with dose of 12.5, 25 or 50 µg/kg in Figure 1A. Figure 1B showed that SA treatment reduced infarct size dose-dependently. (*p<0.05 vs. MCAO group) Neurological outcome 24h after reperfusion improved dose dependently as indicated in Figure 1C. (*p<0.05 vs. MCAO group). MCAO, middel cerebral artery occlusion; SA, salvinorin A.