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Expression profile of claudin genes along the nephron of the kidney. Note that different nephron segments express a unique combination of claudin genes, which may underlie the specific transport functions of these segments. BC: Bowman’s capsule; PT: proximal tubule; TL: thin limb; TAL: thick ascending limb; DCT: distal convoluted tubule; CD: collecting duct; Pod: podocyte; PEC: parietal epithelial cell. Note: the claudin-1 gene is only expressed in podocytes under nephrotic condition.
