Table 3.
Plasma Pharmacokinetic Parameters of L-THP and Cocaine
| Parametera | L-THP n=9 |
Cocaine | |||
|---|---|---|---|---|---|
| Total n=19 |
L-THP n=9 |
Placebo n=10 |
p-value (L-THP vs Placebo) |
||
| Cmax (ng/mL) | 42.8 (62.8)c | 93.8 (47.2) | 83.3 (56.3) | 104.5 (37.3) | 0.46 |
| Tmax (h)b | 1.5c | 0.8 | 0.8 | 0.8 | NA |
| t½ (h) | 13.3 (84.9) | 1.7 (49.4) | 1.5 (64.0) | 1.8 (33.8) | 0.74 |
| CL/F (L/h) | 75.7 (115.2) | 169 (38.8) | 189 (50.7) | 153 (23.4) | 0.14 |
| AUC0→∞ (h*ng/mL) | 396.1 (115.2) | 236.4 (38.8) | 211.5 (50.7) | 261.4 (23.4) | 0.43 |
| AUC0→last (h*ng/mL) | 310.0 (113.8) | 224.6 (40.3) | 200.7 (53.3) | 248.5 (23.8) | 0.47 |
a
Data are presented as geometric mean (geometric CV%) with the exception of Tmax
b
Tmax is presented as median
c
Three subjects who discontinued on Day 3 were included in this parameter estimation, resulting in n=12
NA: Not available