Table 3. Cox proportional hazards regression analysis of risk factors for sputum culture conversion within 3 months among 218 patients with multidrug-resistant tuberculosis.
| Risk factors | Total | Conversionan (%) | Multivariate | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | Pb value | HR (95% CI) | Pb value | |||
| BMI of <18.5 kg/m2 | 53 | 30 (56.6) | 1.974 (1.191–3.272) | 0.008 | 1.741 (1.006–3.013) | 0.047 |
| Age of ≥40 years | 110 | 74 (67.3) | 1.286 (0.795–2.081) | 0.305 | 1.304 (0.767–2.218) | 0.327 |
| Male sex | 164 | 110 (67.1) | 1.548 (0.843–2.842) | 0.158 | 1.724 (0.878–3.385) | 0.113 |
| Cavitation | 120 | 88 (66.7) | 1.269 (0.737–2.183) | 0.5 | 0.85 (0.481–1.503) | 0.577 |
| Smear positivec | 184 | 118 (64.1) | 11.276 (1.564–81.298) | 0.016 | 8.44 (1.146–62.138) | 0.036 |
| Side effects | 82 | 57 (69.5) | 0.899 (0.547–1.478) | 0.675 | 1.115 (0.642–1.935) | 0.7 |
| FQ resistance | 48 | 30 (62.5) | 1.523 (0.885–2.621) | 0.129 | 1.64 (0.890–3.021) | 0.113 |
| ID resistance | 92 | 60 (65.2) | 1.190 (0.736–1.924) | 0.477 | 1.029 (0.612–1.731) | 0.914 |
aWithin 3 months after the initiation of therapy.
bBoldface indicates a significant difference compared to the baseline characteristics.
cThe sputum smear was positive at the initiation of therapy.
HR, hazard ratio; CI, confidence interval; BMI, body mass index; FQ, fluoroquinolone; ID, injectable drug.