Figure 2. Effects of taurine-upregulated gene 1 (TUG1) on cell proliferation, cell cycle and cell apoptosis in MCF-7 cells. (A) The interference efficiency of si-TUG1, si-TUG1 2, and si-TUG1 3 on the expression of TUG1. (B) MTT assay showed that si-TUG1, si-TUG1 2, and si-TUG1 3 significantly reduced proliferation rate of MCF-7 cells. (C, D) si-TUG1 suppressed cell cycle progression in MCF-7 cells analyzed by flow cytometry. The bar chart represented the percentage of cells in G1–G0, S, or G2–M phase, as indicated. (E, F) TUG1 knockdown induced cell apoptosis of MCF-7 cells. Data represent mean±SD (n=6, each).

si-NC=control si-RNA; OD=optaical density.

^*p<0.05 vs. si-NC.