Table 2. Clinicoradiologic features depending on the upgrade in intraductal papilloma without atypia in the univariate analysis.
| Characteristic | Not upgrade (n = 220) No. (%) |
Upgrade (n = 14) No. (%) |
p-value |
|---|---|---|---|
| Age (yr) | |||
| Mean ± SD | 45.1 ± 10.2 | 54.8 ± 11.9 | < 0.001 |
| < 55 | 185 (84.1) | 7 (50.0) | 0.001 |
| ≥ 55 | 35 (15.9) | 7 (50.0) | |
| Mass size (cm) | |||
| Mean ± SD | 1.1 ± 1.2 | 1.6 ± 1.0 | 0.085 |
| ≤1 | 141 (64.1) | 4 (28.6) | 0.002 |
| >1 | 79 (35.9) | 10 (71.4) | |
| Multifocality | 0.630 | ||
| Negative | 159 (72.3) | 10 (71.4) | |
| Positive | 61 (27.7) | 4 (28.6) | |
| BI-RADS category | 0.528 | ||
| 0 | 1 (0.5) | 0 | |
| 1 | 1 (0.5) | 0 | |
| 2 | 2 (0.9) | 0 | |
| 3 | 36 (16.4) | 2 (14.3) | |
| 4 | 177 (80.5) | 12 (85.7) | |
| 5 | 3 (1.4) | 0 | |
| Breast density* | < 0.001 | ||
| 1 | 6 (2.7) | 0 | |
| 2 | 26 (12.0) | 7 (50.0) | |
| 3 | 107 (48.6) | 6 (42.9) | |
| 4 | 81 (36.8) | 1 (7.1) | |
| Location | 0.493 | ||
| Central | 119 (54.1) | 6 (42.9) | |
| Peripheral | 101 (45.9) | 8 (57.1) | |
| Concordance | 1.000 | ||
| Concord | 208 (94.5) | 13 (92.9) | |
| Discord | 12 (5.5) | 1 (7.1) | |
| Palpability | 0.092 | ||
| Negative | 188 (85.5) | 10 (71.4) | |
| Positive | 32 (14.5) | 4 (28.6) | |
| Nipple discharge | 0.085 | ||
| Negative | 155 (70.5) | 12 (85.7) | |
| Positive | 65 (29.5) | 2 (14.3) | |
| Hx. of benign breast disease | 0.852 | ||
| Negative | 194 (88.2) | 13 (92.9) | |
| Positive | 26 (11.8) | 1 (7.1) | |
| Hx. of breast cancer | 1.000 | ||
| Negative | 215 (97.7) | 14 (100) | |
| Positive | 5 (2.3) | 0 | |
| F/Hx. of breast cancer | 1.000 | ||
| Negative | 201 (91.4) | 13 (92.9) | |
| Positive | 19 (8.6) | 1 (7.1) |
BI-RADS =Breast Imaging Reporting and Data System; Hx. =history; F/Hx.=family history.
*Mammographic density by BI-RADS classification system (breast density: type 1, almost entirely fat, glandular tissue is less than 25%; type 2, scattered fibroglandular tissues, ranging from 25% to 50% of the breast; type 3, heterogeneously dense parenchyma, ranging 51% to 75% of the breast tissue; type 4, the breast contains greater than 75% glandular and fibrous tissue).