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. 2016 Dec 19;2016:4131324. doi: 10.1155/2016/4131324

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Copyright © 2016 Han Lei et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Detection of humoral and cellular immune response elicited by HA surface-displayed vaccines in immunized mice. Sera were collected from vaccinated mice and tested for production of (a) HA-specific IgG antibodies at day 13 (n = 21 mice/group), day 28 (n = 21 mice/group), and 5 months (n = 5 mice/group) after prime immunization and (b) IgG isotypes. (c) The numbers of IFN-γ/IL-4 secreting T cells in vaccinated mice. Splenocytes were isolated from vaccinated mice at day 10 (n = 3 mice/group) and day 24 (n = 3 mice/group) after the prime immunization and evaluated by ELISpot. Data are represented as mean ± SD. Asterisk indicates significant difference, as compared to the controls (PBS and EBY100/pYD1 injected mice) (^∗ p < 0.05).