Figure 2.

Coevolution of conserved features signify subfunctionalization of MAD and BUB after MADBUB duplication. (a) Average clustering based on Pearson distances of conserved ancestral feature correlation matrix (distance = 1 − r) of all MADBUB paralogues from figure 1. Red and blue indicate co-presence or -absence of features in the same paralogue, respectively. (b) Evolutionary scenario of MADBUB subfunctionalization: MAD (cytosol) as a SAC effector and BUB (kinetochore) involved in SAC signal formation and kinetochore microtubule attachment.