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. 2016 Nov;11(11):1712–1726. doi: 10.4103/1673-5374.194708

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Psychotropic effects on neurodegeneration, neurogenesis, and behavior.

The effects of quetiapine (QTP), valproate (VPR), lithium (Li), fluoxetine (FLX), donepezil (DNP), and memantine (MMT) are displayed for specific steps in the neuropathic process, derived from preclinical models relevant to Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD) regarding both pre-symptomatic and early clinical stages of these diseases. Therapeutic effects of psychotropic drugs are indicated by blue text on an aqua background while potentially adverse effects are indicated by white text on a red background. Arrowheads signify upregulation, facilitation, or promotion whereas lines ending in perpendicular bars signify downregulation, inhibition, or reduction. Aβ: Amyloid beta; APP: amyloid precursor protein; BDNF: brain derived neurotrophic factor; PS1: presenilin 1; RNS: reactive nitrogen species; ROS: reactive oxygen species.