Table 2.
Results from multivariate logistic models testing the association between τPCr (s) and likelihood (odds ratio) of having prediabetes or being in a higher tertile of HOMA index, Matsuda index, and reduced Matsuda index
| Likelihood of prediabetes | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model I (age, sex, and %PCr depletion adjusted) (N = 248) | Model II* (N = 248) | Model III§ (N = 248) | ||||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||||
| τPCr (s) | 1.05 (1.03–1.08) | <0.001 | 1.06 (1.02–1.09) | <0.001 | 1.06 (1.03–1.10) | <0.001 | ||||||||||
| Model IV† (N = 247) | Model V# (N = 248) | Model VI** (N = 248) | Model VII‡ (N = 248) | |||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||
| τPCr (s) | 1.07 (1.03–1.10) | <0.001 | 1.06 (1.03–1.09) | <0.001 | 1.05 (1.02–1.09) | <0.001 | 1.06 (1.03–1.09) | <0.001 | ||||||||
| Higher tertile of HOMA index (IR) | ||||||||||||||||
| Model I (age, sex, and %PCr depletion adjusted) (N = 248) | Model II* (N = 248) | Model III§ (N = 248) | ||||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||||
| τPCr (s) | 1.04 (1.01–1.06) | 0.002 | 1.04 (1.01–1.07) | 0.002 | 1.04 (1.01–1.07) | 0.003 | ||||||||||
| Model IV† (N = 247) | Model V# (N = 248) | Model VI** (N = 248) | Model VII‡ (N = 248) | |||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||
| τPCr (s) | 1.05 (1.02–1.08) | 0.001 | 1.04 (1.01–1.07) | 0.003 | 1.03 (1.01–1.06) | 0.015 | 1.05 (1.02–1.08) | 0.001 | ||||||||
| Higher tertile of Matsuda index (insulin sensitivity) | ||||||||||||||||
| Model I (age, sex, and %PCr depletion adjusted) (N = 248) | Model II* (N = 248) | Model III§ (N = 248) | ||||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||||
| τPCr (s) | 0.96 (0.94–0.98) | 0.001 | 0.96 (0.93–0.99) | 0.004 | 0.96 (0.93–0.99) | 0.003 | ||||||||||
| Model IV† (N = 247) | Model V# (N = 248) | Model VI** (N = 248) | Model VII‡ (N = 248) | |||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||
| τPCr (s) | 0.95 (0.92–0.98) | 0.001 | 0.96 (0.93–0.98) | 0.003 | 0.97 (0.94–0.99) | 0.011 | 0.95 (0.93–0.98) | 0.001 | ||||||||
| Higher tertile of reduced Matsuda index (insulin sensitivity) | ||||||||||||||||
| Model I (age, sex, and %PCr depletion adjusted) (N = 248) | Model II* (N = 248) | Model III§ (N = 248) | ||||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||||
| τPCr (s) | 0.95 (0.93–0.97) | <0.001 | 0.95 (0.92–0.98) | <0.001 | 0.95 (0.92–0.98) | <0.001 | ||||||||||
| Model IV† (N = 247) | Model V# (N = 248) | Model VI** (N = 248) | Model VII‡ (N = 248) | |||||||||||||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |||||||||
| τPCr (s) | 0.94 (0.92–0.97) | <0.001 | 0.95 (0.92–0.98) | <0.001 | 0.96 (0.93–0.98) | 0.001 | 0.95 (0.92–0.97) | <0.001 | ||||||||
OR, odds ratio.
*Age, sex, %PCr depletion, race, education, smoking status, physical activity level, body weight, body height, and DEXA-measured trunk FM.
§Age, sex, %PCr depletion, race, education, smoking status, physical activity level, body weight, body height, DEXA-measured trunk FM, and plasma levels of IL-6, CRP, leptin, and adiponectin.
†Age, sex, %PCr depletion, race, education, smoking status, physical activity level, body height, body weight, waist circumference, and plasma levels of IL-6, CRP, leptin, and adiponectin.
#Age, sex, %PCr depletion, race, education, smoking status, physical activity level, body weight, body height, DEXA-measured TBFM, and plasma levels of IL-6, CRP, leptin, and adiponectin.
**Age, sex, %PCr depletion, race, education, smoking status, physical activity level, body height, percentage of body fatness, and plasma levels of IL-6, CRP, leptin, and adiponectin.
‡Age, sex, %PCr depletion, race, education, smoking status, physical activity level, BMI, and plasma levels of IL-6, CRP, leptin, and adiponectin.