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Islet cell hormone levels (A: insulin; B: C-peptide; C: proinsulin; D: glucagon) in response to bolus administration of arginine (arrows) under fasting, ∼230 mg/dL, and ∼340 mg/dL hyperglycemic clamp conditions in PS-CF (closed circles), PI-CF (open circles), and healthy control subjects (normal range given as the 95% CI and shown as gray shaded area). CF subject data are represented at mean ± SE. *P < 0.05; **P < 0.01.
