Table 3.
Control subjects (n = 11) | PS-CF (n = 9) | PI-CF (n = 11) | Overall P value |
|||
---|---|---|---|---|---|---|
Control subjects vs. PI-CF | Control subjects vs. PS-CF | PS-CF vs. PI-CF | ||||
Fasting insulin (μU/mL) | 7.4 (6.8–10.4) | 8.8 (6.6–9.1) | 9.1 (6.2–10.4) | 0.85 | ||
AIRarg (μU/mL) | 19.2 (13.7–46.3) | 41.3 (36.4–49.8) | 19.6 (13.9–31.3) | 0.01 | ||
0.82* | 0.03* | 0.003* | ||||
AIRpot (μU/mL) | 99.8 (82.6–128.7) | 162.3 (125.2–227.2) | 56.1 (42.9–94.7) | 0.002 | ||
0.006* | 0.17* | 0.002* | ||||
AIRmax (μU/mL) | 120.4 (91.7–190.2) | 116.7 (83.7–233.8) | 75.6 (52.4–143.0) | 0.13 | ||
Fasting C-peptide (ng/mL) | 1.3 (1.00–1.8) | 1.6 (1.0–1.8) | 1.2 (0.8–1.2) | 0.70 | ||
ACRarg (ng/mL) | 1.2 (0.9–2.2) | 2.0 (1.6–2.6) | 0.8 (0.5–1.2) | 0.004 | ||
0.07* | 0.05* | 0.002* | ||||
ACRpot (ng/mL) | 4.9 (4.3–5.5) | 6.7 (4.4–7.2) | 2.2 (1.5–3.4) | 0.003 | ||
0.004* | 0.52* | 0.003* | ||||
ACRmax (ng/mL) | 6.0 (3.8–6.9) | 5.5 (3.6–7.0) | 3.2 (1.5–4.4) | 0.03 | ||
0.02* | 0.90* | 0.04* | ||||
Fasting glucagon (pg/mL) | 62 (53–74) | 47 (43–60) | 48 (25–62) | 0.09 | ||
AGRarg (pg/mL) | 73 (39–94) | 62 (51–74) | 29 (17–38) | 0.008 | ||
0.02* | 0.73* | 0.003* | ||||
AGRinh (pg/mL) | 42 (33–53) | 33 (28–51) | 16 (15–30) | 0.015 | ||
0.007* | 0.67* | 0.003* | ||||
AGRmin (pg/mL) | 33 (27–51) | 37 (19–43) | 20 (8–29) | 0.03 | ||
0.01* | 0.79* | 0.05* | ||||
Fasting proinsulin (pmol/L) | 8.6 (2.4–22.8) | 10.8 (2.0–13.1) | 11.7 (8.6–21.6) | 0.18 | ||
APRarg (pmol/L) | 5.3 (3.2–9.6) | 7.1 (6.0–11.9) | 2.7 (0.8–6.4) | 0.07 | ||
APRpot (pmol/L) | 23.1 (18.2–30.9) | 29.9 (17.7–33.5) | 18.7 (17.6–22.4) | 0.15 | ||
APRmax (pmol/L) | 22.2 (15.2–26.7) | 19.0 (13.1–19.5) | 16.8 (13.1–19.5) | 0.20 | ||
Fasting proinsulin-to-C-peptide ratio (%) | 2.3 (1.2–2.5) | 1.9 (1.7–2.4) | 3.4 (2.9–4.0) | 0.04 | ||
0.01* | 0.9* | 0.09* | ||||
PISR, fasting (%) | 1.3 (1.0–1.6) | 1.1 (1.0–1.6) | 1.1 (0.3–1.7) | 0.90 | ||
PISR, 230 mg/dL (%) | 1.3 (1.2–1.6) | 1.4 (0.8–1.6) | 2.5 (1.3–3.4) | 0.04 | ||
0.03* | 0.62* | 0.03* | ||||
PISR, 340 mg/dL (%) | 1.2 (1.0–1.3) | 0.85 (0.8–1.3) | 1.4 (1.3–3.0) | 0.09 |
Data are medians and IQRs.
*Between-group comparisons performed when overall P value was significant at P ≤ 0.05.