Table 4.
MMTT control subjects (n = 10) | PS-CF (n = 8) | PI-CF (n = 11)# | Overall P value |
|||
---|---|---|---|---|---|---|
Control subjects vs. PI-CF | Control subjects vs. PS-CF | PS-CF vs. PI-CF | ||||
30 min | ||||||
AUCglu (mg ⋅ min/dL) | 540 (276–729) | 447 (272–521) | 462 (268–509) | 0.60 | ||
AUCISR (pmol/L) | 3,041 (1,459–4,721) | 2,857 (1,950–4,201) | 1,033 (200–1,677) | 0.03* | 0.03 | 0.02* |
0.80* | ||||||
AUCISR/AUCglu (mU ⋅ min/mg) | 0.09 (0.07–0.12) | 0.16 (0.10–0.17) | 0.05 (0.03–0.05) | 0.007* | 0.004 | 0.007* |
0.12* | ||||||
AUCGLP-1 (pmol ⋅ min/L) | 32 (21–81) | 91 (52–121) | 16 (10–71) | 0.32* | 0.04 | 0.02* |
0.05* | ||||||
AUCGIP (pg ⋅ min/mL) | 1,367 (734–1,838) | 1,900 (1,048–2,354) | 747 (355–1,195) | 0.11* | 0.04 | 0.02* |
0.34* | ||||||
180 min | ||||||
AUCglu (mg ⋅ min/dL) | 506 (−145 to 2,958) | 3,501 (2,707–5,123) | 5,075 (2,836–7,989) | 0.004* | 0.007 | 0.46* |
0.02* | ||||||
AUCISR (pmol/L) | 25,917 (23,659–28,693) | 53,375 (47,607–58,495) | 26,156 (23,176–49,651) | 0.60* | 0.006 | 0.08* |
0.0004* | ||||||
AUCISR/AUCglu (mU ⋅ min/mg) | 0.13 (−0.93 to 0.19) | 0.26 (0.15–0.35) | 0.13 (0.08–0.16) | 0.13 | ||
AUCGLP-1 (pmol ⋅ min/L) | 395 (278–589) | 577 (230–738) | 216 (103–494) | 0.27 | ||
AUCGIP (pg ⋅ min/mL) | 34,702 (28,526–40,934) | 30,586 (23,471–45,227) | 18,721 (11,502–28,675) | 0.006* | 0.01 | 0.03* |
0.42* |
Data are medians and IQRs. Glu, glucose.
*Between-group comparisons performed when overall P value was significant at P ≤ 0.05;
#n = 9 for AUCISR and AUCISR/AUCglu.