Figure 6.

Dissection of suprachiasmatic nucleus (SCN) circuit-level pacemaking by intersectional genetic approaches. (A) By manipulating components of the transcriptional and posttranslational feedback loop (TTFL) (BMAL, CLOCK) or the TTFL regulator, CK1ɛ, in defined subpopulations of SCN neurons (AVP, NMS, D1aR), it is possible to alter the period and/or the coherence of mouse activity/rest behavioral rhythms. (Redrawn from data in Lee et al. 2015, Mieda et al. 2015, and Smyllie et al. 2016.) (B) Schematic representation (left) of the partially overlapping subpopulations of SCN neurons, and a meta-analysis (right) of putative pace-setting regions. (Redrawn from data in Smyllie et al. 2016.)