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Interaction network. (A) The tricyclic pleuromutilin core and sulfanylacetyl as well as acylcarbamate linker (side chains omitted for clarity), and (B) the C14 side chain extension with nucleotides of the peptidyl transferase center (PTC). Hydrogen bonds are shown as dotted lines (Schlunzen et al. 2004; Davidovich et al. 2007; Eyal et al. 2015).
