Table 2.
Antibacterial activity of lefamulin and comparators
| MIC90 (μg/mL) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Species | n | LMU | ERY | CLI | DOX | TGC | LZD | VAN | DAP | LEV | PEN |
| Organisms causing predominantly SSSI and bacteremia | |||||||||||
| Staphylococcus aureus | 5527 | 0.12 | >4 | >2 | 0.25 | 0.25 | 1 | 1 | 0.5 | >4 | – |
| MSSA | 3157 | 0.12 | >4 | ≤0.25 | 0.25 | 0.25 | 2 | 1 | 0.5 | 1 | – |
| MRSA | 2370 | 0.25 | >4 | >2 | 1 | 0.25 | 1 | 1 | 0.5 | >4 | – |
| CoNS | 878 | 0.12 | >4 | >2 | 2 | 0.25 | 1 | 2 | 0.5 | >4 | – |
| Enterococcus faecium | 536 | 4 | >4 | – | >8 | 0.25 | 1 | >16 | 2 | >4 | – |
| Vancomycin-nonsusceptible | 304 | 0.25 | >4 | – | >8 | 0.25 | 1 | >16 | 2 | >4 | – |
| β-Haemolytic Streptococcus spp. | 763 | 0.03 | >4 | >2 | 8 | 0.06 | 1 | 0.5 | 0.25 | 1 | 0.06 |
| Viridans group Streptococcus spp. | 245 | 0.5 | >4 | ≤0.25 | >8 | 0.06 | 1 | 0.5 | 0.5 | 2 | 0.5 |
| n | LMU | ERY | AZI | DOX | TGC | LEV | SXT | CXM | IMI | PEN | |
| Organisms causing predominantly RTI | |||||||||||
| Streptococcus pneumoniaea | 1473 | 0.25 | >4 | >4 | 8 | 0.06 | 1 | >4 | 8 | 0.5 | 4 |
| Haemophilus influenzaeb | 360 | 2 | 8 | 2 | 0.5 | 0.25 | – | >4 | 2 | 1 | – |
| Moraxella catarrhalis | 253 | 0.25 | 0.25 | ≤0.25 | 0.25 | 0.25 | – | ≤0.5 | 2 | ≤0.12 | >4 |
| Legionella pneumophilac | 30 | 0.5 | 0.25 | 0.12 | – | – | 0.12 | – | – | – | – |
| Mycoplasma pneumoniae | 50 (4)d | 0.006 | 0.0025–0.005f | ≤0.0003f | 0.04–0.04f | – | – | – | – | – | – |
| Chlamydia pneumoniae | 50 (2)e | 0.04 | 0.04–0.16f | 0.08–0.16f | 0.04–0.08f | – | – | – | – | – | – |
Data adapted from Paukner et al. (2013c) and Sader (2012b).
MRSA, Methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus; CoNS, coagulase-negative Staphylococcus spp.; AZI, azithromycin; CLI, clindamycin; CXM, cefuroxime; DAP, daptomycin; DOX, doxycycline; ERY, erythromycin; IMI, imipenem; LEV, levofloxacin; LMU, lefamulin; LZD, linezolid; PEN, penicillin; SXT, trimethoprim-sulfamethoxazole; TGC, tigecycline; VAN, vancomycin.
a61.3% of S. pneumoniae isolates were penicillin-susceptible.
b23.6% of H. influenzae isolates were β-lactamase-positive.
cMICs determined by agar dilution using charcoal-supplemented BCYEα medium.
dLMU was tested against n = 50 isolates, whereas comparators were tested against n = 4 isolates.
eLMU was tested against n = 50 isolates, whereas comparators were tested against n = 2 isolates.
fRange of MICs for isolates tested.