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. 2016 Dec 1;30(23):2581–2595. doi: 10.1101/gad.289439.116

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© 2016 Luo et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 6. — The role of UCHL3 in response to PARP inhibition and irradiation. (A) Expression of UCHL3 in human breast epithelial cell lines and breast carcinoma cell lines. (B) Correlation between 3554 cases of breast cancer patient survival and UCHL3 expression. (C–E) Survival assays for control and UCHL3 knockout MDA-MB-231 cells stably expressing control or RAD51 shRNA exposed to olaparib (D) and IR (E). (C) UCHL3 and RAD51 expression was detected by Western blot. (F–H) Survival assays for control or RAD51-depleted MCF7 cells stably expressing HA-UCHL3 exposed to olaparib (G) and IR (H). (F) HA-UCHL3 and RAD51 expression was detected by Western blot. (D,E,G,H) Error bars represent SEM from three independent experiments.