Figure 5.

Ablation of the molecular clock results in a loss of electrophysiological rhythm. (A) Relative proportions of firing phenotypes from IPCs in per⁰¹ flies in the morning (ZT 0–4), evening (ZT 8–12), and night (ZT 16–20) showed nearly identical proportions of firing versus nonfiring cells and a loss of cells displaying burst firing events. (B–E) Event frequency, resting membrane potential (RMP), tonic action potential (AP) half-width, and action potential (AP) amplitude from per⁰¹ flies at ZT 0–4 (black), ZT 8–12 (red), and ZT 16–20 (blue). Each point represents a single cell, and horizontal lines indicate the mean. There were no significant differences between time points for any parameter.