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. Author manuscript; available in PMC: 2017 Jan 2.
Published in final edited form as: Front Biosci (Landmark Ed). 2009 Jan 1;14:2386–2399. doi: 10.2741/3385

Figure 1.

Figure 1

The PKC superfamily. PKC isoforms contain four structurally conserved domains (C1-C4). The N-terminal regulatory domain contains a pseudosubstrate binding site (PS), and the DAG (C1) and Ca++ C2, or “C2-like”) binding sites. The catalytic terminal domain contains the ATP binding domain (C3), the substrate binding site, and the kinase domain (C4). The regulatory and catalytic domains are separated by a flexible hinge region which is the site of cleavage of PKC-delta by caspase-3 in apoptotic cells.