Table 2. Pattern of histopathological presentation of well-differentiated thyroid carcinoma according to age.
| Age | p value | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤ 24 yo | 25–44 yo | 45–64 yo | ≥ 65 yo | Total | ||||||||
| Mean (SD) | 20.10 (2.79) | 35.78 (5.75) | 53.25 (5.20) | 71.05 (5.39) | 47.75 (14.32) | – | ||||||
|
Tumoral Diameter
Median (Min-Max) |
1.9 (0.1 - 7) | 1.5 (0.1 - 7) | 1.2 (0.04 - 7.6) | 1.25 (0.1 - 10) | 1.3 (0.04 - 10) | <0.001 | ||||||
| N | % | N | % | N | % | N | % | N | % | – | ||
| Gender | Male | 5 | 17.2 | 35 | 17.6 | 46 | 17.7 | 18 | 24.0 | 104 | 18.5 | 0.633 |
| Female | 24 | 82.7 | 163 | 82.3 | 213 | 82.2 | 57 | 76.0 | 457 | 81.4 | ||
| Histology (CA) | Papillary | 26 | 89.6 | 192 | 96.9 | 248 | 95.7 | 64 | 85.3 | 530 | 94.4 | <0.001 |
| Follicular | 3 | 10.3 | 6 | 3.0 | 11 | 4.2 | 11 | 14.6 | 31 | 5.5 | ||
| Neural or lymphovascular invasion | 8 | 27.5 | 22 | 11.1 | 21 | 8.1 | 12 | 16.0 | 63 | 11.2 | 0.007 | |
| Multifocality | 9 | 31.0 | 75 | 37.8 | 99 | 38.2 | 23 | 30.6 | 206 | 36.7 | 0.574 | |
| Gland capsule invasion | 22 | 75.8 | 103 | 52.0 | 134 | 51.7 | 39 | 52.0 | 298 | 53.1 | 0.097 | |
| Extraglandular invasion | 12 | 41.3 | 50 | 25.2 | 73 | 28.1 | 28 | 37.3 | 163 | 29.0 | 0.111 | |
| Positive neck LN | 12 | 41.3 | 51 | 25.7 | 55 | 21.2 | 9 | 12.0 | 127 | 22.6 | 0.008 | |
| Lateral compartment positive LN | 4 | 29.0 | 24 | 12.1 | 15 | 5.7 | 6 | 8.0 | 49 | 8.7 | 0.081 | |
Abbreviations: CA, Carcinoma; LN, Lymph node; PD, Poorly differentiated; yo, years old.
Note: Variables were expressed in absolute (N) and relative frequencies (%); Mean (Standard Deviation) or Median (Minimum to maximum) were used according to appropriate; diameter was expressed in centimeters; p = level of significance. Post-hoc analysis followed Kruskal-Wallis test when analyzing diameter. Statistically significant differences were observed between: 25-44 yo and 45-64 yo (p = 0.002); 45-64 yo and ≥ 65 yo (p = 0.002); ≤ 24 yo and 45-64 yo (p = 0.015).