Table 1.

Age-independent effects of stimulus valence on brain recruitment.

				MNI Coordinates
Region	Hemisphere	# Voxels	F	x	y	z
Aversive > Neutral and Neutral > Aversive*
Aversive > Neutral:
Temporoparietal junction, middle occipital gyri	R	10401	280.64	51	−63	6
Inferior frontal gyrus	R	199	45.56	42	24	−15
Inferior frontal gyrus	R	217	66.33	45	3	30
Inferior frontal gyrus	R	205	53.35	51	27	−3
Inferior and middle frontal gyri	R	70	37.76	54	15	39
Inferior frontal gyrus	R	199	53.58	54	33	6
Inferior frontal gyrus	R	253	79.79	57	18	27
Middle frontal gyrus	R	234	86.96	39	0	42
Superior temporal gyrus	R	309	66.22	57	−45	15
Superior temporal gyrus	R	103	56.30	45	−45	15
Temporoparietal junction, middle occipital gyri	L	1381	248.06	−48	−72	6
Superior parietal lobule	R	142	40.20	27	−72	33
Fusiform gyrus	R	285	268.15	45	−54	−15
Fusiform gyrus	R	594	236.82	45	−66	−9
Fusiform gyrus	L	265	106.82	−39	−51	−18
Cerebellum	L	342	72.21	−15	−78	−30
Neutral > Aversive:
Anterior insula	R	133	77.29	36	6	9
Mid insula	R	75	29.97	42	3	−9
Posterior insula	R	317	100.53	51	−3	3
Posterior insula	R	273	56.96	39	−15	12
Posterior insula	R	168	51.38	42	−33	21
Posterior insula	R	99	32.68	36	−24	3
Hippocampus, parahippocampal gyrus	L	192	73.17	−30	−48	−3
Hippocampus, parahippocampal gyrus	R	62	49.88	33	−42	−6
Parahippocampal gyrus	L	71	33.17	−21	−33	−21
Parahippocampal gyrus	R	89	33.07	27	−36	−18
Parahippocampal gyrus, fusiform gyrus	R	195	59.87	27	−51	0
Precentral gyrus	R	496	70.81	57	−9	12
Cuneus	L	311	124.17	−12	−69	21
Cuneus	R	323	112.79	12	−57	6
Cuneus	R	421	106.26	12	−69	21
Cuneus	L	316	105.78	−6	−78	27
Cuneus	L	347	87.14	−9	−57	3
Cuneus	R	192	81.41	9	−69	0
Cuneus	L	229	72.57	−9	−81	3
Cuneus	L	230	68.63	−6	−87	18
Cuneus, cerebellum	L	149	103.93	−6	−72	−6
Cerebellum	R	85	62.56	9	−69	−9
Cerebellum	L	121	26.70	−21	−57	−18
Aversive > Neutral
Inferior frontal gyrus	L	201	29.03	−54	15	24
Inferior frontal gyrus	L	34	23.70	−54	15	33
Inferior frontal gyrus	L	37	23.53	−48	3	33
Inferior frontal gyrus	L	58	26.61	−45	12	21
Middle frontal gyrus	L	113	40.52	−30	−3	45
dmPFC	R	705	68.25	3	54	30
dmPFC	R	38	30.87	6	18	57
dmPFC	R	132	30.66	6	30	51
Anterior cingulate	L	42	25.18	−9	18	45
Anterior insula	L	274	41.12	−30	24	−3
Anterior insula	L	43	33.92	−36	18	−21
Inferior frontal gyrus	L	20	27.40	−51	36	−9
Inferior frontal gyrus	L	61	21.98	−42	33	−6
Hippocampus	R	260	71.03	30	−27	−3
Hippocampus	R	29	31.65	30	−12	−15
Amygdala	R	21	26.81	33	−3	−18
Midbrain	L	43	37.57	−6	−33	−6
Midbrain	L	22	20.49	−3	−21	−15
Midbrain	R	44	34.16	6	−33	−6
Thalamus	R	211	30.24	6	−9	3
Thalamus	L	30	26.88	−9	−6	0
Thalamus	R	37	26.56	6	−15	12
Caudate	R	34	22.78	12	3	15
Caudate	R	35	26.17	12	9	6
Ventral striatum	L	24	24.25	−12	6	0
Temporoparietal junction	L	41	25.91	−60	−39	30
Superior parietal lobule	L	412	70.47	−27	−51	48
Inferior parietal lobule	L	108	25.90	−42	−33	39
Superior parietal lobule	R	362	109.43	27	−48	45
Superior parietal lobule	R	208	89.85	27	−54	54
Cerebellum	R	247	41.82	9	−78	−39
Cerebellum	M	83	34.95	0	−54	−36
Cerebellum	R	92	35.01	9	−75	−30
Neutral > Aversive
Middle frontal gyrus	L	118	29.60	−24	18	51
Middle frontal gyrus	L	43	26.68	−21	27	33
Middle frontal gyrus	R	188	27.36	36	36	30
Middle frontal gyrus	R	37	23.45	30	39	21
Middle frontal gyrus	R	83	22.23	39	45	21
vmPFC	L	229	34.56	−9	39	−9
vmPFC	R	108	33.65	12	36	−9
Pregenual cingulate	L	28	17.47	−3	30	3
Inferior temporal gyrus	R	52	26.56	69	−27	−21
Superior temporal gyrus	L	1886	71.51	−57	−6	3
Superior temporal gyrus	L	220	66.60	−66	−24	6
Superior temporal gyrus	L	167	56.36	−51	3	−6
Superior temporal gyrus	L	283	54.76	−54	−15	12
Mid insula	L	133	59.73	−33	3	9
Posterior insula	L	178	49.92	−36	−36	21
Posterior insula	L	132	47.23	−30	−21	15
Posterior insula	L	135	43.34	−36	−21	3
Posterior insula	L	70	33.29	−42	−21	−6
Middle temporal gyrus	L	61	26.91	−66	−45	−12
Precentral gyrus	L	162	53.69	−48	−12	48
Precentral gyrus	L	60	41.02	−33	−18	42
Inferior temporal gyrus	L	23	17.02	−57	−36	−18
Posterior cingulate	L	2056	70.99	−6	−36	36
Posterior cingulate	R	133	68.02	12	−36	39
Anterior cingulate	R	168	53.93	6	6	36
Mid cingulate	L	61	25.88	−6	0	42
Mid cingulate	R	37	21.77	12	−15	42
Pre SMA	R	84	53.86	6	3	45
Supplementary Motor Area	M	168	51.40	0	−3	60
Supplementary Motor Area	R	130	46.64	9	−9	60
Paracentral lobule	R	155	62.21	6	−30	48
Paracentral lobule	R	45	18.71	9	−42	63
Postcentral gyrus	R	142	46.14	51	−12	48
Postcentral gyrus	R	231	37.30	21	−30	57
Postcentral gyrus	L	106	36.33	−21	−30	57
Postcentral gyrus	R	114	20.68	42	−24	60
Precentral gyrus	R	93	35.16	36	−18	42
Precentral gyrus	L	69	29.17	−18	−21	57
Precentral gyrus	R	33	20.64	60	0	39
Superior parietal lobule	L	93	39.21	−18	−39	63
Inferior parietal lobule	L	396	45.32	−36	−75	39
Inferior parietal lobule	L	136	38.57	−45	−66	45
Inferior parietal lobule	L	97	34.09	−42	−57	45
Inferior parietal lobule	L	24	25.60	−39	−84	36
Inferior parietal lobule	R	278	34.89	51	−66	39
Inferior parietal lobule	R	74	28.75	39	−66	42
Inferior parietal lobule	R	114	32.15	51	−51	45

Brain regions identified by the main effect of stimulus valence. For hemisphere, R = right, L = left, M = medial. F = maximum F statistic for a given cluster. *A single large cluster was identified by the main effect of valence term but regions within this cluster varied according to whether they responded more strongly to negative and neutral stimuli. Subclusters that contained 20 or more voxels are reported under their supracluster.