Table 1.
Greater than four-fold upregulated and downregulated genes in granulosa cells of lamb after ovarian superstimulation treatment compared with ewe controls
| Genes | Description | log2Fold change | q-value |
|---|---|---|---|
| Upregulated | |||
| FGL2 | Fibrinogen-like 2 | 4.09 | 4.99×10−4 |
| COL6A6 | Collagen, type VI, alpha 6 | 3.88 | 5.47×10−5 |
| CDCP1 | CUB domain containing protein 1 | 3.39 | 8.33×10−6 |
| HTRA3 | HtrA serine peptidase 3 | 3.26 | 6.58×10−4 |
| GRIK2 | Glutamate receptor, ionotropic, kainate 2 | 3.08 | 6.02×10−4 |
| APOA2 | Apolipoprotein A-II | 3.06 | 1.01×10−12 |
| CAPN6 | Calpain 6 | 2.84 | 1.19×10−3 |
| REG4 | Regenerating islet-derived family, member 4 | 2.70 | 5.27×10−23 |
| LPL | Ovis aries lipoprotein lipase (LPL) | 2.38 | 1.98×10−3 |
| SERPINA14 | Ovis aries serpin peptidase inhibitor, member 14 (SERPINA14) | 2.37 | 3.43×10−5 |
| COBLL1 | Cordon-bleu WH2 repeat protein-like 1 | 2.19 | 5.36×10−48 |
| CEMIP | Cell migration inducing protein, hyaluronan binding | 2.14 | 2.70×10−3 |
| CDO1 | Cysteine dioxygenase type 1 | 2.06 | 1.25×10−78 |
| Downregulated | |||
| IL1RL1 | Interleukin 1 receptor-like 1 | −7.12 | 3.31×10−32 |
| SV2C | Synaptic vesicle glycoprotein 2C | −5.91 | 7.06×10−5 |
| CA5A | Carbonic anhydrase VA, mitochondrial | −5.49 | 2.28×10−5 |
| OXT | Oxytocin-neurophysin 1 precursor | −5.25 | 6.04×10−51 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | −4.60 | 4.29×10−45 |
| TMEM52B | Transmembrane protein 52B | −4.26 | 4.80×10−10 |
| PIWIL2 | Uncharacterized protein | −3.92 | 2.36×10−3 |
| RGS4 | Ovis aries regulator of G-protein signaling 4 | −3.48 | 1.18×10−5 |
| CLEC1B | C-type lectin domain family 1, member B | −3.44 | 6.46×10−5 |
| STC1 | Stanniocalcin 1 | −3.37 | 4.89×10−6 |
| CXorf57 | Chromosome X open reading frame 57 | −3.35 | 1.84×10−13 |
| SPP1 | Osteopontin precursor | −3.27 | 1.45×10−17 |
| NOV | Nephroblastoma overexpressed | −3.05 | 9.67×10−6 |
| IL6R | Interleukin 6 receptor | −2.42 | 1.99×10−7 |
| KCNK12 | Potassium channel, subfamily K, member 12 | −2.39 | 1.16×10−16 |
| NRP1 | Neuropilin 1 | −2.39 | 6.87×10−62 |
| MT1A | Metallothionein-1A | −2.38 | 2.04×10−12 |
| SEMA3A | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | −2.19 | 6.94×10−5 |
| ADAMTS9 | ADAM metallopeptidase with thrombospondin type 1 motif, 9 | −2.10 | 1.09×10−9 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | −2.00 | 5.54×10−19 |