Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 4;7(12):899–912. doi: 10.1007/s13238-016-0316-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

The role of miR-10a targeting BCL6 in the regulation of cell cycle in DLBCL cells. (A) Cell cycle profiles were analyzed using flow cytometry afer the transfection of OCI-LY7 cells with equal dose of control siRNA, BCL6 siRNA, control vector or BCL6 overexpression vector. (B) Cell cycle profiles were analyzed using flow cytometry afer the transfection of OCI-LY7 cells with equal dose of pre-miR-control, pre-miR-10a, anti-miR-control or anti-miR-10a. (C) Cell cycle profiles were analyzed using flow cytometry afer the transfection of OCI-LY7 cells with pre-miR-control plus control vector, a pre-miR-control plus BCL6 overexpression vector, pre-miR-10a plus control vector, or pre-miR-10a plus BCL6 overexpression vector. The panel shows hisograms of cell numbers (y axis) against DNA content (x axis) determined by measuring fluorescence intensity. Numbers denote the percentages of cells in the G0/G1, S and G2/M phases. Left panel: representative image; right panel: quantitative analysis. Data are the mean ± SEM of 3 independent experiments performed in triplicate, ** P < 0.01; *** P < 0.001

The role of miR-10a targeting BCL6 in the regulation of cell cycle in DLBCL cells. (A) Cell cycle profiles were analyzed using flow cytometry afer the transfection of OCI-LY7 cells with equal dose of control siRNA, BCL6 siRNA, control vector or BCL6 overexpression vector. (B) Cell cycle profiles were analyzed using flow cytometry afer the transfection of OCI-LY7 cells with equal dose of pre-miR-control, pre-miR-10a, anti-miR-control or anti-miR-10a. (C) Cell cycle profiles were analyzed using flow cytometry afer the transfection of OCI-LY7 cells with pre-miR-control plus control vector, a pre-miR-control plus BCL6 overexpression vector, pre-miR-10a plus control vector, or pre-miR-10a plus BCL6 overexpression vector. The panel shows hisograms of cell numbers (y axis) against DNA content (x axis) determined by measuring fluorescence intensity. Numbers denote the percentages of cells in the G0/G1, S and G2/M phases. Left panel: representative image; right panel: quantitative analysis. Data are the mean ± SEM of 3 independent experiments performed in triplicate, ** P < 0.01; *** P < 0.001