Fig. 5.

Mechanism leading to the generation of a single hetero-cluster inverted architecture. The patterns were generated from P0. a Nuclear size and shape are fixed under conditions (3)–(5), defined in the text. The parameters used are the same as in Fig. 4, except for ${\mathit{\rho }}_m(t)=0$. b The heterochromatin conversion rate is fixed for a fixed-sized nucleus, and circular and elliptical nuclei that decrease in size (80 % cut-off) under conditions (4)–(5), defined in the text. The parameters used are the same as in Fig. 4, except for $({\overline{\mathit{\rho }}}_1,{\overline{\mathit{\rho }}}_2,{\overline{\mathit{\rho }}}_3,{\overline{\mathit{\rho }}}_4,{\overline{\mathit{\rho }}}_5,{\overline{\mathit{\rho }}}_6,{\overline{\mathit{\rho }}}_7,{\overline{\mathit{\rho }}}_8)=(0.0,0.0,0.0,0.0,0.0,0.0,0.0,0.0)$. c The affinity between the nuclear envelope and heterochromatin is present for a fixed-sized nucleus and circular and elliptical nuclei that decrease in size (80 % cut-off) under conditions (3) and (5), defined in the text. The parameters used are the same as in Fig. 4, except for $\mathit{\gamma }=0.022$. (d) The unoccupied space in the nucleus is considered a fixed nucleus and circular and elliptical nuclei that decrease in size (40 % cut-off) under conditions (3) and (4), defined in the text. The final volumes of euchromatin and heterochromatin decrease to approximately 49 % compared with P0 volumes, in each panel. The parameters used are the same as in Fig. 4