Fig. 1.

L-type calcium current (I_Ca,L) and action potentials (APs) of the modified rabbit ventricular cell model. A: peak I_Ca,L vs. holding voltage under voltage clamp for different maximum conductance values of I_Ca,L [G_Ca,L, mmol/(cm,C)]. Note that a 5-fold increase in G_Ca,L (from 50 to 250) resulted in roughly a 3-fold increase in peak I_Ca,L. B: AP under normal control condition (dashed), G_Ca,L = 40 mmol/(cm,C), and AP under LQT2 condition (solid), in which we set G_Kr = 0 from the normal control condition. Pacing cycle length was 1 s.